2024.07.29 ACE-ing protein detection in single cells

Mass cytometry with signal amplification enables measurement of low 1 abundance proteins, Nature Biotechnology ACE nanotech art – ACE technology enables highly multiplexed and sensitive signal amplification to detect proteins in single cells using suspension mass cytometry single-cell suspension and imaging mass cytometry analysis. This illustration shows how proteins in individual cells of a tissue section can be quantified with ACE-enhanced antibodies binding to them. Credit: Su Min Suh/SciStories ACE technology graphic – This illustration explains how ACE is used to create a structure containing multiple identical nonradioactive metal isotopes (upper box). The team designed blueprints for synthesizing 33 different ACE structures on antibodies that to enable the multiplexed and highly sensitive detection of proteins in suspension mass cytometry and imaging mass cytometry analysis. Credit: Wyss Institute at Harvard University