2023.06.07 - New, spun-fiber heart valve is a step closer to patients

PR title (tentative): New, spun-fiber heart valve is a step closer to patients Paper title: On Demand Heart Valve Manufacturing Using Focused Rotary Jet Spinning Pub date: June 7, 2023 in Matter Peters_ValveSpinning_V1: This time-lapse video shows the FibraValve being manufactured using focused rotary jet spinning (FRJS) in less than 10 minutes. Credit: Wyss Institute at Harvard University FibraValveLeafletMotion: The leaflets of the FibraValve open and close like a functional heart valve when subject to conditions that mimic the flow of blood through it. Credit: Wyss Institute at Harvard University FRJS Schematic: A polymer and focused jets of air are forced through the spinning device, and fibers of the polymer collect on a valve-shaped mandrel to form the FibraValve. Credit: Wyss Institute at Harvard University Valvecellsonscaffold: After two days of incubation with living heart valve cells, a significant number of the cells had adhered to the FibraValve, indicated here with fluorescent colors. Credit: Wyss Institute at Harvard University Matter_FibraValve_Cover: This representation of the FibraValve and FRJs appeared on the cover of Matter. Credit: Michael Rosnach, Wyss Institute at Harvard University Valvewithfiberzoomin: The FibraValve is composed of long filaments of polymer fibers, which replicate the physical properties of a human heart valve and are porous enough to allow cells to infiltrate and replace the scaffold with living tissue. Credit: Wyss Institute at Harvard University