2025.07.02 Forging a novel therapeutic path for patients with Rett Syndrome with AI

Manuscript title: AI-enabled drug prediction and gene network analysis reveal therapeutic use of vorinostat for Rett Syndrome in preclinical models Publication Date: July 1, 2025 Journal: Communications Medicine Figure 3: The team found in their study that tadpoles engineered to develop Rett-like disease exhibited disordered and significantly increased acetylation (yellow immunofluorescence staining) of α-tubulin filaments (magenta immunofluorescence staining) (middle), compared to normal tadpoles (left). Importantly, treating the engineered tadpoles with vorinostat normalized the acetylation levels and organization of α-tubulin filaments again. Credit: Wyss Institute at Harvard University Multi-photon Xenopus brain: This image shows a tadpole preparation which was stained for acetylated a-tubulin protein. Credit: Wyss Institute at Harvard University