2025.05.15 - ENTERing a new era of drug delivery

ENTER Schematic.jpg - This drawing shows how the ENTER system is internalized by a cell, breaks out of the endosome, and delivers a gene-editing cargo into the nucleus. Credit: Wyss Institute at Harvard University Fig 1i.png - This microscopy image shows the ENTER constructs, composed of spheres of ELPs containing EEPs inside. Credit: Wyss Institute at Harvard University Fig 1i - colorized.png - This microscopy image shows the ENTER constructs, composed of spheres of ELPs containing EEPs inside. Credit: Wyss Institute at Harvard University Fig 6d-e - These images demonstrate cells that are producing the red fluorescent protein, indicating that ENTER has successfully delivered Cre recombinase that has edited their genomes. Multiple cell types are represented across the large and small airways of a mouse, showing that ENTER can be used to target a variety of cells and diseases. Credit: Wyss Institute at Harvard University