Wyss Institute
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2022.XX.XX - New type of RNA discovered that inhibits viral infections

PR title: New type of RNA discovered that inhibits viral infections Paper title: Self-assembling short immunostimulatory duplex RNAs with broad- spectrum antiviral activity Journal title: Molecular Therapy - Nucleic Acids Pub date: 10/05/2022 Captions: dsRNA_Fig. 4B: The dsRNAs have a motif of one cytosine (C) and three guanines (G) on one end. These overhangs can bind to each other via Hoogsteen base pairing, creating a dimer that potently binds to RIG-I and stimulates the production of interferon-I (IFN-I). Credit: Wyss Institute at Harvard University isRNA for flu and COVID-19_Blue and Teal 3x2: The introduction of the novel dsRNAs into living cells induces IFN-I production in cells’ nuclei. Credit: Wyss Institute at Harvard University isRNA for flu and COVID-19_Composite: The introduction of the novel dsRNAs into living cells induces IFN-I production in cells’ nuclei (right, in light blue), while the introduction of scrambled control dsRNA does not (left). Credit: Wyss Institute at Harvard University