2024.08.07 - 3D-printed blood vessels bring artificial organs closer to reality

PR title: 3D-printed blood vessels bring artificial organs closer to reality Paper title: Embedding Biomimetic Vascular Networks via Coaxial Sacrificial Writing into Functional Tissue Journal: Advanced Materials Paper link: https://onlinelibrary.wiley.com/doi/10.1002/adma.202401528 Captions: Branching and Reconnection Techniques.mp4 - This video demonstrates two different methods of linking 3D-printed vessels together using the co-SWIFT method. Credit: Lori K. Sander SWIFT_noScaleBar and co-SWIFT_noScaleBar composite.png - The original SWIFT method (left) printed hollow channels through living OBBs (green), but had no structure to contain fluid as it flowed through. Co-SWIFT (right) creates a cell-laden vessel (red) surrounding the channel, which isolates blood flow from the tissue and improves their viability. Credit: Wyss Institute at Harvard University LCA Video.mp4: This video demonstrates co-SWIFT printing a patient-specific pattern of blood vessels from the left coronary artery into both OBBs (left) and alginate beads (right). Credit: Lori K. Sander ManyOrderVesselNetwork.jpg: co-SWIFT prints 3D vessels that consist of an outer "shell" and an inner "core" that can be easily connected to each other to create a branching network of vasculature that can support living human tissues. Credit: Wyss Institute at Harvard University PrintedVesselNetwork.png: co-SWIFT vessels are embedded with living smooth muscle cells and endothelial cells to replicate the structure of human blood vessels in vitro. Credit: Wyss Institute at Harvard University