2023.01 Attacking COVID-19’s moving antibody target

Figure illustration: In the eRapid electrochemical sensor approach taken by the Wyss Institute team, eRapid chips protected with an anti-fouling nanocomposite coating were engineered to carry probes that specifically detect patients’ antibodies against the SARS-CoV-2 nucleocapsid (N) protein. Upon binding of the antibodies from small blood samples, a precipitation reaction creates an electrical signal that corresponds in strength with the antibody levels bound to the sensor. Credit: Wyss Institute at Harvard University eRapid photo: The Wyss Institute’s eRapid electrochemical sensor platform enables the multiplexed, fast, and inexpensive detection of biomarker molecules specific for infectious and other diseases at the point-of-care. Credit: Wyss Institute at Harvard University