2025 Recapitulating egg and sperm development in the dish

Press release title: Recapitulating egg and sperm development in the dish Homepage title: Egg and sperm development in a dish Article title: Initiation of meiosis from human iPSCs under defined conditions through identification of regulatory factors Journal: Science Advances Meiotic features in iPSC-derived cells induced to differentiate as eggs and sperm: This fluorescence microscopy image shows induced pluripotent stem cells (iPSCs) that, for the first time, have been induced to enter and partially proceed through meiosis, a key process during the development of eggs and sperm, in a culture dish. The punctate marker shown in green indicates that the meiotic cells’ chromosomes started to pair and exchange genetic information. Credit: Wyss Institute at Harvard University