Building big with DNA gets a software upgrade

Building big with DNA gets a software upgrade A computational framework for designing micron-scale crisscross DNA megastructures, Nature Communications Caption: The team used their easily accessible computational framework, #-CAD, to design and fabricate a series of complex Crisscross DNA megastructures from start to finish. Shown here is a gallery that pairs various #-CAD-assisted design graphics with microscopic images of the final structures. The hexagonal megastructures on the right include additional fluorescent elements that demonstrate how megastructures could be functionalized. Credit: Wyss Institute at Harvard University