2024.01.03 - Using the body’s own cells to treat traumatic brain injury

PNAS_Fig1A_withtext - This schematic demonstrates how the anti-inflammatory backpacks are constructed (bottom left) and injected into subjects (top left) so that they can infiltrate the brain (top right) and shift the injury microenvironment from a pro-inflammatory to an anti-inflammatory state (bottom right). Credit: Wyss Institute at Harvard University ***NOTE: it looks like this image has no background and might need a white one added in Photoshop PNAS_Fig1D - cover image - "A macrophage (green and blue) sports a backpack (red) attached to its surface, which is delivering anti-inflammatory signals to keep the cell in a healing state. Credit: Wyss Institute at Harvard University PNAS_Fig4A and 4B (could you make them into a composite?) - When backpack-bearing macrophages were injected into pigs with a mock TBI, the size of their lesions shrunk dramatically, reducing the amount of brain tissue damaged. Credit: Wyss Institute at Harvard University